Formulation and Evaluation of Metoprolol Succinate Floating Tablets Using Chia Seeds

<p><span>Floating tablets are a special type of drug delivery system that stays in the stomach for a longer time.The development of floating tablets falls under gastroretentive drug delivery systems, aiming to increase drug bioavailability. The aim of the present study is to formulate, develop and characterize gastroretentive floating tablets of Metaprolol Succinate, an Anti-hypertensive drug that acts by blocking β-1 adrenergic receptors. Metaprolol Succinate, is a BCS Class I drug having high solubility and permeability. The objective of the study involves retainment of the drug in the gastric environment to prolong the drug release time. Four formulations were prepared by varying the concentration of chia seeds. The FTIR and DSC studies indicated compatibility between the drug and chia seeds. Fours formulations were prepared by granulation method and were evaluated for various parameters such as tablet hardness, weight variation, friability, floating time and in vitro drug release profile. Formulation FM 3 containing 150mg of chia seeds was optimized as better formulation as 96.54±0.12 of drug was released in 12hrs</span><span>.<span>   </span></span></p>