Relationship between serum homocysteine level and cognitive frailty in elderly patients with H-type hypertension

[Objective] To explore the relationship between serum homocysteine (Hcy) level and cognitive weakness in elderly H hypertensive patients. [Methods] A total of 146 elderly patients with H-type hypertension admitted to Xuanwu Hospital of Capital Medical University from 2022 to 2023 were selected. According to whether they had cognitive frailty, they were divided into cognitive frailty group (31 cases) and non-cognitive frailty group (115 cases). Multivariate logistic regression was used to analyze the influencing factors of cognitive frailty, and ROC curve was used to analyze the predictive value of risk model for cognitive frailty. [Results] There were significant differences in age, Hcy, serum creatinine(Scr)，blood uric acid(BUA), cystatin C(CysC) and vitamin D levels between the cognitive frailty group and the non-cognitive frailty group (P<0.05). Multivariate logistic regression analysis showed that age, Hcy, Scr, BUA , CysC, vitamin D were the independent influencing factors of cognitive frailty (P<0.05). ROC curve analysis showed that the AUC of serum Hcy level in predicting cognitive frailty in elderly patients with H-type hypertension was 0.878 (95% CI: 0.812-0.944, P<0.001), the optimal threshold was 17.655 μmol/L, the sensitivity was 8.71%, the specificity was 7.22%, and the maximum Youden index was 0.593. [Conclusion] There is a significant positive correlation between serum Hcy level and cognitive frailty in elderly patients with H-type hypertension, suggesting that Hcy may be a potential biomarker for cognitive frailty.