中国万人卒中多组学多模态数据库（STROMICS）：提升卒中精准诊疗的宝贵资源 A Comprehensive Multi-omics and Multimodal Database of 10 k Chinese Stroke Patients (STROMICS): A Valuable Resource for Advancing Precision Medicine in Stroke Diagnosis and Treatment

目前全球卒中面临治疗药物有限且新药研发进展缓慢的困境，部分原因在于缺乏基于大规模卒中队列且具有完善随访数据的多组学多模态数据库。STROMICS发布了中国缺血性卒中万人队列的全基因组高深度测序结果。该数据库整合了约1.5万例缺血性卒中患者的蛋白质组学、代谢组学等多组学数据，超过2700项临床表型信息，189个生物指标检测结果，以及多种影像数据、临床检查、诊断、治疗和随访记录；建立了首个中国卒中患者万人队列的多组学多模态数据平台（http://www.stromics.org.cn）。STROMICS的建立填补了此前全球卒中研究领域中国患者多组学多模态数据的空白，是促进卒中机制研究和精准诊疗的宝贵资源。 Abstract: Currently, stroke treatment faces the dilemma of limited therapeutic drugs and slow progress in new drug development globally, partly due to the lack of multi-omics and multimodal databases with comprehensive follow-up data from large-scale stroke cohorts. The Chinese stroke omics atlas (STROMICS) has released the whole-genome sequencing results from a cohort of ten thousand Chinese patients with ischemic stroke. This database integrates multi-omics data, including proteomics, and metabolomics, from approximately 15 000 patients with ischemic stroke. Additionally, it incorporates more than 2700 clinical phenotypes, 189 biomarker test results, various imaging data, clinical examinations, diagnoses, treatments, and follow-up records. By establishing the first multi-omics and multimodal data platform for a cohort of ten thousand Chinese stroke patients (http://www.stromics.org.cn), STROMICS addresses the lack of multi-omics and multimodal data for Chinese patients in the previous global stroke research field. It serves as a valuable resource for promoting stroke mechanism research and precision medicine.