Causal survival embeddings: Non-parametric counterfactual inference under right-censoring

Counterfactual inference at the distributional level presents new challenges with censored targets, especially in modern healthcare problems. To mitigate selection bias in this context, we exploit the intrinsic structure of reproducing kernel Hilbert spaces (RKHS) harnessing the notion of kernel mean embedding. This enables the development of a non-parametric estimator of counterfactual survival functions. We provide rigorous theoretical guarantees regarding consistency and convergence rates of our new estimator under general hypotheses related to smoothness of the underlying RKHS. We illustrate the practical viability of our methodology through extensive simulations and a relevant case study: The SPRINT trial. Our estimatort presents a distinct perspective compared to existing methods within the literature, which often rely on semi-parametric approaches and confront limitations in causal interpretations of model parameters.

Publication Details

Journal
Repository for Publications and Research Data (ETH Zurich)
Published
2025-03-01
DOI
https://doi.org/10.3929/ethz-b-000722566
Primary Topic
Medical Imaging Techniques and Applications
Type
article
Field-Weighted Citation Impact
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article

Causal survival embeddings: Non-parametric counterfactual inference under right-censoring

Repository for Publications and Research Data (ETH Zurich)
Medical Imaging Techniques and Applications
article

Causal survival embeddings: Non-parametric counterfactual inference under right-censoring

article en

Abstract

Counterfactual inference at the distributional level presents new challenges with censored targets, especially in modern healthcare problems. To mitigate selection bias in this context, we exploit the intrinsic structure of reproducing kernel Hilbert spaces (RKHS) harnessing the notion of kernel mean embedding. This enables the development of a non-parametric estimator of counterfactual survival functions. We provide rigorous theoretical guarantees regarding consistency and convergence rates of our new estimator under general hypotheses related to smoothness of the underlying RKHS. We illustrate the practical viability of our methodology through extensive simulations and a relevant case study: The SPRINT trial. Our estimatort presents a distinct perspective compared to existing methods within the literature, which often rely on semi-parametric approaches and confront limitations in causal interpretations of model parameters.

Repository for Publications and Research Data (ETH Zurich)
Reduced inequalities
Openalex Percentile: Top 41%
Medical Imaging Techniques and Applications
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