History of Narcolepsy

Narcolepsy is a chronic disease characterized with excessive daytime sleepiness, cataplexy, and other symptoms like sleep paralysis, hypnogogic hallucination and nocturnal sleep disturbance. This condition is introduced in medical field in late 1880. Changes in the pathophysiological understanding of hypocretin/orexin system, its diagnostic criteria, treatment methods from classic psychostimulants to medication on clinical trials were discussed.