增生性瘢痕动物模型的研究进展

A suitable animal model of hypertrophic scar is of great importance for studying pathogenesis of hypertrophic scar and exploring more efficacious treatment. Researchers have tried to establish hypertrophic scar models in various animals, and the rabbit ear hypertrophic scar model is the most widely used one. In recent years, novel models such as the rat tail hypertrophic scar model and ethanol-induced rabbit ear hypertrophic scar model have been proposed. These models inherit the advantages of traditional models while simplifying the manufacturing process, presenting significant research potential. This paper provides the research advances on animal models of hypertrophic scar in nude mice, mice, rats, rabbits, pigs, guinea pigs, and dogs, offering insights for the researchers in selecting appropriate models, refining existing models, or creating new animal models.