Low pregnenolone levels/-deficiency in patients with rheumatoid arthritis and fibromyalgia syndrome – an interesting biomarker and potential therapeutic target

Introduction: We tested the hypothesis that decreased pregnenolone levels are common in patients with rheumatoid arthritis (RA) and fibromyalgia (FMS). Pregnenolone (PR) synthesis is the first and rate-limiting step in steroidogenesis, in which cholesterol is converted in mitochondria to pregnenolone, [for full text, please go to the a.m. URL]

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Publication Details

Journal
German Medical Science (German Research Foundation)
Published
2024-09-18
DOI
https://doi.org/10.3205/24dgrh169
Primary Topic
Algal biology and biofuel production
Type
article
Field-Weighted Citation Impact
0.00
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article

Low pregnenolone levels/-deficiency in patients with rheumatoid arthritis and fibromyalgia syndrome – an interesting biomarker and potential therapeutic target

German Medical Science (German Research Foundation)
Algal biology and biofuel production
article

Low pregnenolone levels/-deficiency in patients with rheumatoid arthritis and fibromyalgia syndrome – an interesting biomarker and potential therapeutic target

article en

Abstract

Introduction: We tested the hypothesis that decreased pregnenolone levels are common in patients with rheumatoid arthritis (RA) and fibromyalgia (FMS). Pregnenolone (PR) synthesis is the first and rate-limiting step in steroidogenesis, in which cholesterol is converted in mitochondria to pregnenolone, [for full text, please go to the a.m. URL]

German Medical Science (German Research Foundation)
PHV Dialysezentrum (DE), Euro-Centrum (PL)
Good health and well-being
Openalex Percentile: Top 76%
Algal biology and biofuel production
DOIOpen Access PDFOpenAlex
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Low pregnenolone levels/-deficiency in patients with rheumatoid arthritis and fibromyalgia syndrome – an interesting biomarker and potential therapeutic target · German Medical Science (German Research Foundation) (2024) | TGRS Research Map | TGRS