A custom CRISPR-Cas9 library screen to study the impact of single genes on neutrophil function

Introduction: Neutrophils are essential mediators of host defense and pathologic inflammation. We recently described that neutrophils display high plasticity, enabling them to acquire both tissue as well as disease-specific signatures. Now, new approaches are needed to mechanistically study the role [for full text, please go to the a.m. URL]

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Publication Details

Journal
German Medical Science (German Research Foundation)
Published
2024-09-18
DOI
https://doi.org/10.3205/24dgrh019
Primary Topic
Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

A custom CRISPR-Cas9 library screen to study the impact of single genes on neutrophil function

German Medical Science (German Research Foundation)
Neutrophil, Myeloperoxidase and Oxidative Mechanisms
article

A custom CRISPR-Cas9 library screen to study the impact of single genes on neutrophil function

article en

Abstract

Introduction: Neutrophils are essential mediators of host defense and pathologic inflammation. We recently described that neutrophils display high plasticity, enabling them to acquire both tissue as well as disease-specific signatures. Now, new approaches are needed to mechanistically study the role [for full text, please go to the a.m. URL]

German Medical Science (German Research Foundation)
Heidelberg University (DE), University Hospital Heidelberg (DE), Universitätsklinikum Erlangen (DE)
Openalex Percentile: Top 61%
Neutrophil, Myeloperoxidase and Oxidative Mechanisms
DOIOpen Access PDFOpenAlex
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