LINC01433 is a prognostic biomarker and associated with immune infiltrates in glioblastoma

Although long intergenic noncoding 01433 (LINC01433) has been demonstrated as an oncogene in several cancers, its impact on glioblastoma (GBM) is unknown. This study aimed to explore LINC01433 prognostic roles and its relationship to immune infiltrates, as well as to identify its prognostic roles in GBM patients. Logistic regression was used for evaluating the correlation between LINC01433 and clinicopathological characters. Gene Ontology (GO) term analysis, and Gene Set Enrichment Analysis (GSEA) were performed to explore the enrichmental pathways and functions as well as quantify the extent of immune cells infiltration for LINC01433. LINC01433 up-regulation was significantly related to tumor WHO grade, IDH status, 1p/19q co-deletion, and primary treatment outcome (p 0.05). According to nomogram-based calibration plots and C-index, our constructed nomogram achieved high prediction performance for GBM. Based on GSEA, LINC01433 up-regulation might influence neutrophil degranulation, and interferon signaling, exhibiting a positive relationship to innate immunocytes (such as macrophages and eosinophils) levels. A high level of LINC01433 expression was observed in tumor tissues. LINC01433 expression was significantly correlated with poor survival and immune infiltrations in GBM, and it might be a promising prognostic biomarker in GBM.