Evaluation of the Antimicrobial Effects of Mesoporous Silica Nanoparticles Carrying Nanosilver for Endodontic Treatment: A Systematic Review and Meta-analysis

Background and aim: The present study aimed to evaluate the antimicrobial effects of mesoporous silica nanoparticles carrying nanosilver in endodontic treatment. Material and methods: The literature was screened via international databases Cochrane, Embase, and MEDLINE (PubMed and Ovid) up to October 2024 with English language restriction. Two reviewers independently performed screening and evaluation of articles. The ToxRTool® checklist information contained eighteen items to evaluate Methodological quality. The mean difference was used as an effect size indicator to analyze each included study. The random-effect model combined the effect size with the Restricted maximum likelihood method. All meta-analyses were performed using Stata software (version 17). Results: A total of 143 articles were retrieved from all the databases; after applying eligibility criteria, eight studies were included. Biofilm was significantly lower in the nMS-nAg groups compared to the control group (MD: -64.94 95% CI; -76.43,-53,44; P˂0.001). Conclusions: Based on the present meta-analysis, nMS-nAg-Chx showed strong antibacterial activity to reduce biofilms.