The role of TREM-1 in allergic airway inflammation

Asthma affects 25 million Americans, and recent advances in treatment are effective for only a portion of severe asthma patients. TREM-1, an innate receptor that canonically amplifies inflammatory signaling in neutrophils and monocytes, plays a central role in regulating lung inflammation. It is unknown how TREM-1 contributes to allergic asthma pathology. We utilized genetic mouse models and a model of allergic airway inflammation (AAI) to investigate the effects of TREM-1 ablation on AAI disease severity, type 2 immune responses, and myeloid cell function.