Development and performance of a DNA methylation based diagnostic precision biomarker for rheumatoid arthritis

Introduction: Diagnostic delay for seronegative rheumatoid arthritis (RA) is a major clinical problem. To this end, a software algorithm (“EarlyRA”) that utilises epigenetic patterns in patients’ blood for early detection of both seropositive and seronegative RA has been developed. [for full text, please go to the a.m. URL]