The Effect of Nigella Sativa on Lipid Profile, Fasting Blood Sugar and Blood Pressure of Patients: A Meta-Analysis Systematic Review

Background: The impact of Nigella sativa on various health markers have been studied before. The present systematic review and meta-analysis reveals the effect of N. sativa on lipid profile, fasting blood sugar (FBS) and blood pressure.Methods: Relevant studies published up to April 21, 2024 were searched through the PubMed, SCOPUS and google scholar databases to collect all randomized clinical trials that evaluated the effect of N. sativa on FBS, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patients with different conditions. We conducted our study according to the 2020 PRISMA guidelines. Only English language publications were included. Pooled meta-analysis was measured by a random-effect model and were reported as the weighted mean difference (WMD) and 95% confidnce interval (95%CI). Results: Fifteen articles were included in this systematic review and meta-analysis. Our pooled meta-analysis indicated a significant reduction in TG, TC, LDL, SBP, DBP and FBS after administration of N. sativa. Also, a significant increase in HDL was noticed after administration of N. sativa.Conclusion: This meta-analysis demonstrated the decreased effect of N. sativa on FBS, HDL, LDL, TG, TC, SBP and DBP. Further large random clinical trials are required to shed light on this issue.