Magnetic Particle Spectrometry of 3D cancer cell spheroids

Superparamagnetic iron oxide nanoparticles (SPIONs) have a significant role in biomedical applications such as hyperthermia therapy or magnetic particle imaging. This study investigates the loading of 3D cell spheroids made from a pancreas cell line of rats with magnetic nanoparticles. Here, we show the uptake and a homogeneous distribution of nanoparticles in spheroids, while magnetic particle spectrometry (MPS) reveals a measurable difference in the magnetic behavior of nanoparticles in aqueous solution compared to those incorporated into spheroids.