Role of neutrophils and NETs in osteosarcoma and soft tissue sarcoma

Neutrophils are one of the important components of the tumor microenvironment. Neutrophil extra cellular traps (NETs) are a network structure released by neutrophils, and their formation process is called neutrophil inflammatory apoptosis (NETosis). Neutrophils in the tumor microenvironment, also known as tumor associated neutrophils (TANs). TANs including N1 phenotype and N2 phenotype have a bidirectional regulatory effect on tumors. While N1 phenotype inhibits tumor growth, and N2 phenotype promotes tumor growth, and N1 and N2 types undergo mutual transformation due to the influence of the tumor microenvironment. Neutrophils and NETs also play important roles in bone and osteosarcoma tissue sarcoma, which can affect tumor progression and predict patient prognosis. Blocking the formation of NETs may be a potential therapeutic target.