BUB1B and gynecological malignant tumors

The BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) maintains a high fidelity of mitotic chromosome segregation by preventing the initiation of anaphase without the attachment of one or more kinetochore to the spindle, and plays a major role in both signal transduction and the stable attachment of kinetochore to microtubules. The dysregulated expression of BUB1B may affect the occurrence of mitosis-induced aneuploidy, chromosome instability and abnormal cell biological function, leading to cell malignant transformation. This review summarizes the role of BUB1B in the occurrence and development of gynecological malignant tumors.