PBP IC<sub>50</sub> ± SD of β-lactam antibiotics and BLIs in <i>N</i>. <i>gonorrhoeae</i> strains.

<p><sup><i>a</i></sup><i>N</i>. <i>gonorrhoeae s</i>trains ATCC 19424 and ATCC 49226; clinical strains NG 3, NG 7, NG 12, NG 14, NG 19, NG 20, NG 21 from Hospital Universitario Son Espases (Spain) and NG 22 from Hospital Clínic de Barcelona (Spain); and WHO reference strains NCTC 13820 (WHO X), NCTC 13821 (WHO Y) and NCTC 13822 (WHO Z). <sup><i>b</i></sup> PBP, penicillin-binding proteins. <sup><i>c</i></sup> This table shows the concentration of β-lactam required to inhibit 50% of Bocillin FL compared to a control with no drug. The mean values from three experiments are presented. The abbreviations used are as follows: ETP for ertapenem, CFM for cefixime, CTX for cefotaxime, CRO for ceftriaxone, CAZ for ceftazidime, TOL for ceftolozane, PIP for piperacillin, AVI for avibactam, TZ for tazobactam, CAZ/AVI for ceftazidime/avibactam, TOL/TZ for ceftolozane/tazobactam, and PIP/TZ for piperacillin/tazobactam. <sup><i>d</i></sup> When the primary PBP target was not inhibited by the regular concentrations (0.001 to 0.125 mg/L or 0.016 to 2 mg/L), an extended range of 1 to 512 mg/L was used. For CAZ/AVI, TOL/TZ, and PIP/TZ, a fixed concentration of the BLIs avibactam or tazobactam at 4 mg/L was used.</p> <p>(PDF)</p>