Attempted replication of prior GWAS findings.

<p>* SNP not found in MGI dataset. ** Study by Henao-Martinez <i>et al</i>., 2013 used Serum Creatinine (mg/dL) as a marker of renal function (ie: continuous variable), therefore, direct comparison of effect size to our logistic regression, which used KDIGO-staged AKI (ie: binary, categorical variable) is not possible. Studies replicated at <i>P</i> < 0.05 threshold are denoted in <b>bold</b>. <u>Abbreviations</u>: CHF = congestive heart failure; Chr = Chromosome; COPD = chronic obstructive pulmonary disease; GWAS = genome-wide association study; KDIGO = Kidney Disease: Improving Global Outcomes; MAF = Minor Allele; MGI = Michigan Genomics Initiative OR = Odds Ratio; Pos = Position; Frequency; S-AKI = Sepsis-associated Acute Kidney Injury; SOFA = Sequential Organ Failure Assessment; SE = Standard Error; SNP = single nucleotide polymorphism.</p> <p>(DOCX)</p>

Publication Details

Journal
Figshare
Published
2024-12-05
DOI
https://doi.org/10.1371/journal.pone.0311318.s003
Primary Topic
Chronic Kidney Disease and Diabetes
Type
article
Field-Weighted Citation Impact
0.00
Controls
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article

Attempted replication of prior GWAS findings.

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Chronic Kidney Disease and Diabetes
article

Attempted replication of prior GWAS findings.

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Abstract

<p>* SNP not found in MGI dataset. ** Study by Henao-Martinez <i>et al</i>., 2013 used Serum Creatinine (mg/dL) as a marker of renal function (ie: continuous variable), therefore, direct comparison of effect size to our logistic regression, which used KDIGO-staged AKI (ie: binary, categorical variable) is not possible. Studies replicated at <i>P</i> < 0.05 threshold are denoted in <b>bold</b>. <u>Abbreviations</u>: CHF = congestive heart failure; Chr = Chromosome; COPD = chronic obstructive pulmonary disease; GWAS = genome-wide association study; KDIGO = Kidney Disease: Improving Global Outcomes; MAF = Minor Allele; MGI = Michigan Genomics Initiative OR = Odds Ratio; Pos = Position; Frequency; S-AKI = Sepsis-associated Acute Kidney Injury; SOFA = Sequential Organ Failure Assessment; SE = Standard Error; SNP = single nucleotide polymorphism.</p> <p>(DOCX)</p>

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Chronic Kidney Disease and Diabetes
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