Pathways impacted by carvacrol and thymol

. Sina plots depict differential guide CPMs for (A) NADH dehydrogenase and (B) ubiquinone pathways in carvacrol and thymol. Chemical-gene interactions are described above each graph—up (positive), down (negative), or no change—with FDR values. Guides are weighted in this calculation by predicted efficacy, with perfect guides at 100. Volcano plots show relative fitness and FDRs at the gene-level in (C) carvacrol or (D) thymol. Genes in pathways of interest are highlighted, and chemical structures are depicted. (PDF)