Effect of high fat, high fat and high fructose diet on hyperuricemia in rats

[Objective] This study aimed to investigate the effects of high fat diet and high fat and high fructose diet on uric acid level and liver and kidney function in hyperuricemia (HUA) rats. [Methods] 24 rats were randomly divided into control group, model group, high-fat diet group and high-fat and high-fructose diet group. All rats were fed with the corresponding diets, except the control group, 500 mg/kg potassium oxazinate and 100 mg/kg adenine per day. After 6 weeks, serum biochemical indexes such as uric acid and creatinine were determined, and pathological examination of kidney and liver was performed. [Results] The uric acid content of control group, model group, high-fat diet group and high-fat high-fructose diet group were 118.10, 319.05, 325.71, 456.10 μmol/L, respectively. The levels of uric acid and creatinine in the high-fat diet group were not significantly different from those in the model group, but the kidney injury and liver fat accumulation were more serious. The uric acid in the high-fat and high-fructose group was significantly higher than that in the model group, and the degree of kidney injury and liver fat accumulation was more serious than that in the model group. [Conclusion] High-fat diet cannot further increase the uric acid content of HUA rats, but can aggravate the liver and kidney damage of HUA rats. High-fat and high-fructose diet will further increase the uric acid content of HUA rats, and aggravate kidney injury and liver fat accumulation. Hyperuricemia group should pay attention to control the intake of dietary fat and fructose.