Characterization of RBP-binding sites in intron RNAs encoded by different categories of host genes.

<p>(A) Numbers and percentages of host genes encoding mitochondrial proteins annotated in MitoCarta3.0 or cytoplasmic or mitochondrial ribosomal proteins annotated in GRCh38 that contain FLEXIs (top), other short introns (middle), or long introns (bottom) with binding sites for Cluster I RBPs. (B) Numbers and percentages of all host genes for different subsets of introns compared to those for all GRCh38 annotated protein-coding genes. (C) Density plots showing the average coverage of RBP-binding sites across the gene body (Exons CDS + UTRs; black) or intron body (red) calculated using Picard tools normalized by percent length. In the gene body plots, 0% and 100% indicate the 5’ and 3’ ends the mRNAs, respectively. In the intron body plots, 0% indicates the 5’ end of the first intron and 100% indicates the 3’ end of the last intron of the same gene.</p> <p>(PDF)</p>

Publication Details

Journal
Figshare
Published
2024-09-26
DOI
https://doi.org/10.1371/journal.pgen.1011416.s021
Primary Topic
Education Methods and Technologies
Type
article
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article

Characterization of RBP-binding sites in intron RNAs encoded by different categories of host genes.

Figshare
Education Methods and Technologies
article

Characterization of RBP-binding sites in intron RNAs encoded by different categories of host genes.

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Abstract

<p>(A) Numbers and percentages of host genes encoding mitochondrial proteins annotated in MitoCarta3.0 or cytoplasmic or mitochondrial ribosomal proteins annotated in GRCh38 that contain FLEXIs (top), other short introns (middle), or long introns (bottom) with binding sites for Cluster I RBPs. (B) Numbers and percentages of all host genes for different subsets of introns compared to those for all GRCh38 annotated protein-coding genes. (C) Density plots showing the average coverage of RBP-binding sites across the gene body (Exons CDS + UTRs; black) or intron body (red) calculated using Picard tools normalized by percent length. In the gene body plots, 0% and 100% indicate the 5’ and 3’ ends the mRNAs, respectively. In the intron body plots, 0% indicates the 5’ end of the first intron and 100% indicates the 3’ end of the last intron of the same gene.</p> <p>(PDF)</p>

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