Related to Fig 1.

<p>(A) Schematic showing the spindle features extracted for GSPCs from animals bearing mutant alleles in the signaling pathways shown in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011351#pgen.1011351.g001" target="_blank">Fig 1C</a>. Features are shown relative to the spindle length versus time plot from <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011351#pgen.1011351.g001" target="_blank">Fig 1B</a>, indicating which stage of mitosis they relate to. Features are listed on the right with letter designations used in (B-D). (B) Heatmap showing the mitotic features that differ significantly from control in each mutant background. Data were compared using a Kruskal-Wallis with Tukey-Kramer post hoc test with the null hypothesis that all samples come from the same distribution. Red indicates values above the control mean and blue indicates values below the control mean. Color saturation indicates the distance above/below the control mean after data standardization. (C) Heatmap showing the strength of the linear relationship between each spindle feature and the duration of mitosis across all cells of all genotypes. Pearson’s coefficient (r) is shown for significant (<i>p</i> < 0.05 after Bonferroni correction) correlations. (D) Principal component analysis of spindle features showing all cells plotted along the first two principal components, with delayed cells (duration of mitosis > 90th percentile of control) shown for <i>daf-2(e1370)</i>, <i>daf-7(e1372)</i> and <i>glp-1(e2141)</i>. Vectors represent the contribution of each spindle feature to the principal components shown. All data used in this analysis can be found in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011351#pgen.1011351.s009" target="_blank">S1 Data</a>.</p> <p>(PDF)</p>