Construction and clinical application of a perioperative and postoperative home nutritional intervention regimen for children with hepatoblastoma

Objective To construct a perioperative and postoperative home nutritional intervention regimen for children with hepatoblastoma, and to evaluate its clinical application effect. Methods Semi-structured interviews, literature research, and Delphi methods were used to construct a perioperative and postoperative nutritional intervention regimen for children with he-patoblastoma. A total of 31 children with hepatoblastoma who underwent surgery in our hospital from January 2019 to August 2021 were enrolled as control group, and 31 children with hepatoblastoma who underwent surgery from September 2021 to December 2023 were enrolled as experimental group. The children in the control group received routine diagnosis, treatment, and nursing, and those in the experimental group received the nutritional intervention regimen in addition to the intervention in the control group. The two groups were compared in terms of nutritional status, blood biochemical parameters (serum albumin, serum prealbumin, and blood hemoglobin), body height, body weight, and body mass index at 1 week before surgery and at 1 week, 1 month, and 3 months after surgery, and the clinical guiding significance and practical effect of the nutritional intervention regimen was assessed. Results At 1 and 3 months after surgery, compared with the control group, the experimental group had a significant reduction in the numbers of children with mild-to-moderate malnutrition and severe malnutrition (Z=-2.799,-3.697,P<0.05) and significant increases in the levels of serum albumin and blood hemoglobin (F=4.870-111.680,P<0.05). At 1 and 3 months after surgery, both groups had significant increases in serum albumin and hemoglobin compared with the data at 1 week before surgery (F=60.247-1 270.148,P<0.05), and compared with the control group, the experimental group had significantly greater changes in body weight at 1 and 3 months after surgery (compared with the data at 1 week before surgery) (Z=-2.405,-4.716,P<0.05). Conclusion This study successfully constructs a perioperative and postoperative home nutritional intervention regimen for children with hepatoblastoma, and it is shown that this intervention regimen can improve the nutritional status, blood biochemical parameters, and physical development of children, with good scientificity and practicality.