Validation of Alt and ModA ARTs inactivation via Alt E577A and ModA E165A mutations.

<p>(<b>A-B</b>) Stain-free scan (TCE stain, loading control, left) and Western blot analysis (pan-ADPr antibody for ADP-ribosylation detection, right) to identify ADP-ribosylation events by ARTs and their mutants. Both mutants demonstrate complete abolishment of ADP-ribosylation. <i>n =</i> 3 biological replicates, a representative example is shown.</p> <p>(PDF)</p>

Publication Details

Journal
Figshare
Published
2024-09-04
DOI
https://doi.org/10.1371/journal.pgen.1011384.s004
Primary Topic
PARP inhibition in cancer therapy
Type
article
Field-Weighted Citation Impact
0.00
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article

Validation of Alt and ModA ARTs inactivation via Alt E577A and ModA E165A mutations.

Figshare
PARP inhibition in cancer therapy
article

Validation of Alt and ModA ARTs inactivation via Alt E577A and ModA E165A mutations.

article en

Abstract

<p>(<b>A-B</b>) Stain-free scan (TCE stain, loading control, left) and Western blot analysis (pan-ADPr antibody for ADP-ribosylation detection, right) to identify ADP-ribosylation events by ARTs and their mutants. Both mutants demonstrate complete abolishment of ADP-ribosylation. <i>n =</i> 3 biological replicates, a representative example is shown.</p> <p>(PDF)</p>

Figshare
Openalex Percentile: Top 51%
PARP inhibition in cancer therapy
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Validation of Alt and ModA ARTs inactivation via Alt E577A and ModA E165A mutations. · Figshare (2024) | TGRS Research Map | TGRS