Ineffective chemical concentrations lack significant pathway effects.

(A) Volcano plots of genes in meropenem, imipenem, or doripenem compared to no drug control. Genes with significant CG scores are shown in black. Meropenem has very few significant CG scores, suggesting insufficient chemical dosage. (B) Sina plots with boxplots of differential guide CPMs for target pathway in doripenem, imipenem, or meropenem. Chemical interactions compared to no chemical control (up, down, or no change) and FDRs are listed. Non-significant comparison for meropenem is shown with grey background. Doripenem and imipenem are significantly impacted. (PDF)