iKIR score negatively impacts protection associated with <i>DQ6</i> in T1D even when iKIR ligands are included as covariates.

<p>The UK-GRID cohort was stratified into individuals with high or low iKIR score using different cutoffs (1.5, 1.75, 2.0 and 2.5). The protective effect of <i>DQ6</i> was evaluated independently in each stratum using multivariate logistic regression with gender, Bw4, C1 and C2 ligands included in the model as covariates. Overall conclusions were remarkably similar to our previous analysis (not including the ligands as covariates). Regression coefficients, permutation p-values and cohort sizes are reported for the different strata. P-value for the whole cohort (unstratified analysis) calculated using the Wald-test; p-values for the stratification analysis are calculated using the permutation test.</p> <p>(PDF)</p>