Analysis of H3K27ac ChIP and scRNA-seq data sets (related to Figs 4 and 5).

<p>(A) Plots showing distribution of H3K27ac peaks around the TSS (top), annotation of peaks (bottom left), and distribution of peaks relative to TSS in day 5 LP and HP population. (B) UMAP plot showing day 7 cells of the progressive pigmentation model coloured by clusters identified using TF activity (top) and pigmentation (bottom). (C) Heatmap showing top TF active in LP and HP population at day 7 (right). TF activity derived from scRNA data using Dorothea and Viper packages. (D) PCA plot showing expression of Myc (top), E2f (middle), and pigmentation genes (bottom) in the artificial cells simulated using RACIPE. (E) Violin plot showing Mitf expression in differentiating, mature, native, and proliferative melanocyte states in the progressive pigmentation model. (F) Violin plot showing Mitf expression in mature and proliferative states across different scRNA-seq data sets: human epidermal melanocytes (top), day 7 of the progressive pigmentation model (middle) and days 0, 3, and 5 of the progressive pigmentation model. All numerical data are listed in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002776#pbio.3002776.s011" target="_blank">S1 Data</a>.</p> <p>(DOCX)</p>