Photoredox Site-SelectiveC(sp³)–HAlkylation of 1‑(<i>o</i>‑Iodoaryl)-alkan-1-oneswith Activated Alkenes Enabled by Hydrogen Atom Transfer

A visible-light-mediated photoredox catalysis for β-C(sp³)–H alkylation of 1-(<i>o</i>-iodoaryl)alkan-1-ones with alkenes via 1,5-hydrogen atom transfer and alkene alkylarylation to produce diverse β-alkyl arylalkanones containing a quaternary carbon center is presented. This method is applicable to a wide range of 1-(<i>o</i>-iodoaryl)alkan-1-ones and activated alkenes. Mechanistic studies suggest that the reaction involves a radical process.