Predictive value of 3D quantitative shape features based on CT for disease-free survival of primary gastrointestinal stromal tumors

ObjectiveTo explore the predictive value of 3D quantitative shape features based on enhanced CT for disease-free survival (DFS) of primary gastric gastrointestinal stromal tumors (GIST) patients receiving curative resection. MethodsFrom January 2010 to December 2016, a total of 154 patients with primary gastric GIST who received curative resection in Zhongshan Hospital, Fudan University were retrospectively collected. The conventional CT imaging features and 3D quantitative shape features of tumors were evaluated, and the influencing factors of DFS were analyzed by univariate and multivariate Cox regression. Cut-off values were extracted, and Kaplan-Meier curves were used for survival analysis. ResultsMaximum 3D diameter (HR=1.829, 95%CI 1.389-2.408, P＜0.001) and spherical disproportion (HR=2.153, 95%CI 1.474-3.146, P＜0.001) were independent risk factors for DFS in primary gastric GIST. Kaplan-Meier curves showed that patients with maximum 3D diameter＞90.5 mm and spherical disproportion＞1.5 showed shorter DFS after curative resection (P＜0.001). ConclusionMaximum 3D diameter and spherical disproportion based on preoperative enhanced CT are valuable in the diagnosis of postoperative DFS in primary gastric GIST.