Total Synthesis\nand Stereochemical Assignment of Roselipin\n1A

Roselipin 1A, a bioactive natural glycolipid isolated\nfrom marine\nfungal metabolites, presents an unresolved configuration of its nine\nstereogenic centers within the polyketide chain. Herein, we elucidate\nthe comprehensive stereostructure of roselipin 1A through an integrative\napproach combining predictive rule-guided analysis with synthetic\nchemistry. The efficient total synthesis facilitated the unequivocal\nconfirmation of the hypothesized stereochemistry for roselipin 1A,\nthereby establishing its precise molecular configuration.