Simultaneous determination of 13 non-phthalate plasticizers in strong-flavor Baijiu by gas chromatography-mass spectrometry

A method for the simultaneous determination of 13 non-phthalate plasticizers in strong-flavor (Nongxiangxing) Baijiu by gas chromatography- mass spectrometry (GC-MS) was established. The alcohol content of sample was diluted with water to about 20%vol, then extracted with n-hexane, and then extracted twice by vortex, ultrasound and centrifugation. The extracted solution was combined and concentrated by nitrogen blowing and then re-dissolved. The chromatographic column was Agilent HP-5MS column (30 m×0.25 mm×0.25 μm), the inlet temperature was 280 ℃, and the initial temperature of column oven was 70 ℃. A variety of non-phthalate plasticizers were detected by select ion monitoring (SIM) mode and quantified by external standard method. The results showed that the 13 non-phthalate plasticizers had a good linear relationship in the range of 0.02-1.0 mg/L, the correlation coefficient (R²)≥0.996 2, the limit of detection (LOD) were 0.002-0.05 mg/kg, and the limit of quantification (LOQ) were 0.006-0.15 mg/kg; The average standard recovery rates were 55.9%-113.8%, and the relative standard deviation (RSD) of precision tests results were 1.0%-8.8%. The method was accurate, efficient, rapid and simple, and could be used for the qualitative and quantitative detection of a variety of non-phthalate plasticizers in Baijiu.