Trifluoromethylthiolation Carbonylation of Unactivated\nAlkenes via Distal Migration

Sulfur-containing\ncompounds represent a significant category of\norganic compounds, and the introduction of sulfur groups into organic\ncompounds can effectively enhance their biological activity and synthetic\ndiversity. Although a variety of difunctionalization reactions of\nalkenes based on sulfur radicals have been documented, significant\nchallenges remain in the carbonylative difunctionalization of unactivated\nalkenes by the addition of a sulfur radical. Herein, we present a\ntrifluoromethylthiolative carbonylation reaction of unactivated alkenes,\nwhich goes through the addition of a trifluoromethylthiol radical\nto unactivated alkenes and then carbonylation of the newly generated\ncarbon radical intermediate. A heterocyclic/aryl migration in the\npresence of carbon monoxide is crucial for the success of this methodology\nand finally resulted in the formation of sulfur-containing carbonylated\nproducts in good yields.