Bifunctionalization\nof α‑Bromophenone:\nAn Access to Functionalized β‑Keto Thiosulfones

A simple\nand high-yielding strategy to produce a variety of β-keto\nsulfides using asymmetrical and symmetrical thiosulfonates with ketones\nunder mild conditions is reported. It was found that the various substituted\ncompounds, with both electron-withdrawing and electron-donating substituents,\nafforded a wide range of β-keto thiosulfones (α-thioaryl-β-keto\nsulfones) in moderate to high yields. The transformations were reliable\nat the gram-scale, thus illustrating their efficiency and practicality.\nA plausible mechanism for the protocol is also proposed.