Construction of C4-SpirocyclicChiral Covalent OrganicFrameworks Via Asymmetric Multicomponent Povarov Reaction for EnantioselectiveSensing

Although many chiral covalent organic frameworks (CCOFs) have been synthesized, the rapid development of this field has been severely restricted by the limitations of CCOFs synthesis methods and the scarcity of their chiral structural unit types. Herein we report, for the first time, the construction of C4-spirocyclic CCOFs via the asymmetric multicomponent Povarov reaction under ambient conditions. The obtained <b>C4</b>-<b>spiro</b>-(2<i>S</i>, 4<i>R</i>)-<b>TMTT</b>-<b>COF</b> can be as a novel chiral fluorescent sensor to discriminate D/L-PAL enantiomers. This finding will provide a simple and universal method for constructing CCOFs with novel chiral structural groups and might open new insights into the construction of the CCOFs featuring multiple distinct types of carbon chiral centers.