Synthesis of\nβ‑Silyl Amines via Merging\nPhotoinduced Energy and Hydrogen Atom Transfer in Flow

The development of efficient methods for synthesizing\nβ-silyl\namines has long been a significant goal in organic synthesis. Previous\nmethods mainly relied on the use of prefunctionalized substrates or\nspecial reagents. Herein, we present a visible-light-promoted synthesis\napproach for β-silyl amines, utilizing a combination of photoinduced\nenergy and hydrogen atom transfer processes. Using flow chemistry\ntechnology, a variety of valuable skeletons, including β-silyl\namines and α-amino esters, can be produced from readily available\nfeedstocks such as hydrosilanes and simple alkanes. Moreover, the\nstrategy’s full-process fluidized production capability highlights\nits potential for industrial-scale manufacturing. Mechanistic studies\nrevealed that oxime esters can act as radical precursors as well as\nhydrogen atom transfer reagents.