Dr Spur's mystery case HSV : can it be a clue to an underlying inborn error of immunity?

HSV - can it be a clue to an underlying inborn error of immunity? I was recently contacted by a wife, concerned about her previously healthy 54-year-old husband, who suddenly complained of a severe headache. She noticed that he had difficulty speaking and seemed to be of balance. I arranged with a specialist physician at the nearest hospital for emergency admission. A diagnosis of herpes simplex virus (HSV) type-1 encephalitis was made. The patient made a full recovery after a full course of intravenous acyclovir.