Amino-Based Probe for Natural Products with Covalent\nBinding Ability to Lysine and Mechanism of Action of Medermycin

A chemoselective\namino-based probe was designed for discovering\nnatural products with covalent binding potential to lysine. Using\nthis reactivity-based technique, a marine-derived Streptomyces strain was identified, which could produce medermycin as the major\nmetabolite. A new compound, mederpyrrole A, derived from medermycin\nand anthranilic acid through nonenzymatic reaction was isolated. Medermycin\ncan react with primary amines under mild conditions to generate chimeric\nproducts possessing a naphthoquinone-pyrrole skeleton. It can also\ncovalently bind to proteins.