Nickel-CatalyzedDynamic Kinetic Asymmetric ReductiveArylation of Aldehydes with Heterobiaryl Triflates

In this context, we report a nickel-catalyzed dynamic kinetic asymmetric reductive arylation of aldehydes with racemic heterobiaryl triflates, offering a series of axially chiral heterobiaryls bearing a centrally chiral secondary alcohol moiety in a highly diastereo- and enantioselective manner. The simultaneous control of both axial and central stereogenic elements of the products lies in the stereoselective nucleophilic addition of the configurationally labile hetereobiaryl nickel complex to the formyl group of aldehydes.