Nanoenabled Antiviral\nPesticide for Tobacco Mosaic\nVirus: Excellent Adhesion Performance and Strong Inhibitory Effect\nto Alleviate the Damage on Photosynthetic System

Tobacco mosaic virus (TMV) is a major agricultural threat.\nHere,\na cationic star polymer (SPc) was designed to construct an efficient\nnanodelivery system for moroxydine hydrochloride (ABOB). ABOB could\nself-assemble with SPc via a hydrogen bond and van der Waals force,\nand this complexation reduced the particle size of ABOB from 2406\nto 45 nm. With the aid of SPc, the contact angle of ABOB decreased\nfrom 100.8 to 79.0°, and its retention increased from 6.3 to\n13.8 mg/cm<sup>2</sup>. Furthermore, the complexation with SPc could\nattenuate the degradation of ABOB in plants, and the bioactivity of\nSPc-loaded ABOB significantly improved with a reduction in relative\nviral expression from 0.57 to 0.17. The RNA-seq analysis revealed\nthat the ABOB/SPc complex could up-regulate the expression of growth-\nand photosynthesis-related genes in tobacco seedlings, and the chlorophyll\ncontent increased by 2.5 times. The current study introduced an efficient\nnanodelivery system to improve the bioactivity of traditional antiviral\nagents.