Enantioselective\nSynthesis of <i>P</i>‑Chiral\nPhosphine Oxides Bearing an All-Carbon Quaternary Stereogenic Center\nvia Palladium-Catalyzed Domino Heck–Suzuki Reaction

An approach has been developed for the enantioselective\nsynthesis\nof <i>P</i>-chiral phosphine oxides bearing an all-carbon\nquaternary stereogenic center via a Pd-catalyzed domino Heck–Suzuki\nreaction. The origin of the mechanistic preference leading to high\ndiastereo- and enantioselectivities under the Pd catalysis based on\na TADDOL-derived phosphoramidite ligand was rationalized on the basis\nof DFT calculations.