Palladium-Catalyzed\nEnantioselective Synthesis of\nP(V)-Stereogenic Compounds via Desymmetric Annulation of Prochiral\nPhosphinamides and Aryl Iodides

The enantioselective synthesis of P(V)-stereogenic compounds\nhas\nemerged as an interesting research topic primarily due to their significant\nbiological activity and broad application prospects. Herein, we disclose\na method for the construction of P(V)-stereogenic compounds from prochiral\nphosphinamides and aryl iodides via palladium- and chiral norbornene-catalyzed\ndesymmetric annulation. The P(V)-stereogenic compounds were formed\nwith a broad scope with excellent enantiomeric excesses. It is noteworthy\nthat the synthetic value of this procedure was proven by a variety\nof transition metal-catalyzed cross-coupling reactions using the C–Br\nbond on the product as a versatile linchpin electrophile.