Oxy-difluoroallylation\nof Ynamides by Nickel-Catalyzed\nTandem Alkoxylation/Claisen Rearrangement

A nickel-catalyzed tandem alkoxylation/claisen\nrearrangement\nstrategy\nfor the oxy-difluoroallylation of ynamides has been developed. In\nthis reaction, 3,3-difluoroallyl alcohol was used as a fluorine-containing\nbuilding block to construct the C–CF<sub>2</sub> bond for the\nfirst time. This approach is recognized for its robust tolerance of\nfunctional groups, impressive yields, and excellent atomic efficiency,\nall achieved under mild reaction conditions. A series of β,β-difluoromethyleneamide\nderivatives were efficiently obtained through simple operations, and\ntheir practicality was confirmed through gram-scale synthesis and\nproduct derivatization.