Bimetal-Driven Nucleotide\nNanosheets for Spontaneously\nEnhanced Antibacterial and Protective Coatings

The propagation of pathogenic bioaerosols leads to severe\nrespiratory\nailments in humans, posing a significant risk to public health. At\npresent, most personal protective equipment (PPE) utilized to prevent\nthe transmission and infection of pathogenic bioaerosols lacks antimicrobial\nfunctionality. Herein, the antibacterial nanosheets (Co-GMP@AgNSs)\nwere designed and synthesized to coordinate guanosine monophosphate\n(GMP) with Co ions to form nanosheets by solvent-thermal strategy,\nfollowed by in situ growth of silver nanoparticles (AgNPs). To obtain\nantibacterial PPE, the porous Co-GMP@AgNSs with high surface area\nare integrated into polypropylene (PP) fiber to form the PP@Co-GMP@AgNSs\ncomposite. Due to the oxidase-like activity of PP@Co-GMP@AgNSs, oxygen\nmolecules (O<sub>2</sub>) were persistently and effectively converted\ninto reactive oxygen species (ROS) without requiring external stimulation.\nMoreover, the inherent antibacterial ability of AgNPs further enhanced\nthe antibacterial efficacy, resulting in an antibacterial effect of\n99%. During the 8 cycles of testing, the antibacterial efficiency\nof the PP@Co-GMP@AgNSs coating was consistently over 90% against MRSA,\ndemonstrating its remarkable antibacterial durability. MTT assay solidly\nconfirmed the good biocompatibility. Therefore, metal-nucleotide\nnanozymes with antimicrobial activity could offer a kind of safe and\ncheap material for developing reusable antibacterial face masks.