Dicitrinols A–C:\nCitrinin Derivatives from\nHydrothermal Vent-Associated Fungus <i>Penicillium citrinum</i> TW132-59

Three new unusual citrinin derivatives with a unique\n6/5/7/5 core,\ndicitrinols A–C (<b>1</b>–<b>3</b>, respectively),\nwere isolated via the fermentation of hydrothermal vent-associated\nfungus <i>Penicillium citrinum</i> TW132-59. Their structures\nwere unambiguously determined by nuclear magnetic resonance, mass\nspectrometry, and electronic circular dichroism calculations. Dicitrinols\nA–C represent a novel cage carbon skeleton with a decahydro-5,9,4-(epipropane[1,1,3]triyl)cycloocta[<i>b</i>]furan ring system. Dicitrinols A–C showed moderate\nantifungal activity against <i>Candida albicans</i>, <i>Cryptococcus neoformans</i>, and <i>Fusarium oxysporum</i> and antibacterial activity against <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and <i>Acinetobacter\nbaumannii</i> with minimum inhibitory concentrations ranging\nfrom 4 to 16 μg/mL.