Rhodium-Catalyzed\nC–H Arylation of Indoles\nwith Arylsilanes at Room Temperature

The Cp*Rh-catalyzed C–H arylation of indoles with\narylsilanes\nis developed. This C–H activation transformation allows for\nthe Rh-catalyzed indole C<sub>2</sub> arylation to overcome the limitations\nof requiring strong directing group assistance and high-temperature\nconditions, achieving a room-temperature transformation driven by\na weak directing group. Cp*Rh/MeOH catalytic media are considered\na key factor enabling this transformation to occur under mild conditions,\nand experimental studies and theoretical calculations were performed\nto rationalize the reaction mechanisms and the influence of methanol\nas a solvent in promoting the reaction.