Electrochemical\nDehydrogenative sp<sup>2</sup>‑Coupling\nReaction of Naphthols Accessing a Polycyclic Naphthalenone Motif

A novel polycyclic naphthalenone motif was obtained by\nelectrochemical\nsynthesis starting from naphthols. The process is solvent controlled,\nand the highly diastereoselective cyclization is due to a solvent\ncage. The direct, anodic dehydrogenative sp<sup>2</sup>-coupling was\ncarried out by flow electrolysis. Ten derivatives containing this\nmotif were synthesized in yields up to 88%, resulting in novel polycycles\nstructurally similar to bioactive compounds like Daldionin, potentially\nexploring the bioactive profile.