Cu(II)/Photoredox-CatalyzedAminoacylation of VinylBromides

A novel C–C coupling reaction of vinyl bromides with carboxamides has been developed through Cu(OAc)<sub>2</sub>/photocatalysis. This process features regioselective carboxamido carbon-vinylation under mild reaction conditions. Mechanistic studies suggest that the formation of an acyl-Cu(I) intermediate plays a crucial role with regard to enabling this transformation.

Publication Details

Journal
Figshare
Published
2025-03-24
DOI
https://doi.org/10.1021/acs.orglett.5c01104.s001
Primary Topic
Catalytic C–H Functionalization Methods
Type
article
Field-Weighted Citation Impact
0.00
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article

Cu(II)/Photoredox-CatalyzedAminoacylation of VinylBromides

Figshare
Catalytic C–H Functionalization Methods
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Cu(II)/Photoredox-CatalyzedAminoacylation of VinylBromides

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Abstract

A novel C–C coupling reaction of vinyl bromides with carboxamides has been developed through Cu(OAc)<sub>2</sub>/photocatalysis. This process features regioselective carboxamido carbon-vinylation under mild reaction conditions. Mechanistic studies suggest that the formation of an acyl-Cu(I) intermediate plays a crucial role with regard to enabling this transformation.

Figshare
Openalex Percentile: Top 59%
Catalytic C–H Functionalization Methods
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Cu(II)/Photoredox-CatalyzedAminoacylation of VinylBromides · Figshare (2025) | TGRS Research Map | TGRS