Diversity Oriented\nRoutes to Thiopeptide Antibiotics:\nA Solution to the “Thiazole Problem”

The Goossen decarboxylative coupling reaction enables\nthe union\nof thiazole-2-carboxylic acids with a 2-pyridyl triflate, leading\nto the formation of pyridine-thiazole clusters of the kind found in\nthiopeptide antibiotics. The method avoids problematic or technically\nchallenging reaction sequences involving 2-thiazolyl organometallics,\nfacilitating the investigation of the structure–activity relationship\nof the thiopeptides.