Palladium-Catalyzed\nCross-Coupling of Aryl Bromides\nand Chlorides with Trimethylsilylalkynes under Mild Conditions

Herein, we disclose a palladium-catalyzed\ncross-coupling\nof aryl\nbromides and chlorides with trimethylsilylalkynes under mild reaction\nconditions. This method utilizes commercially available and air stable\npalladium precatalysts and avoids the use of copper cocatalysts. Moreover,\nit allows for the synthesis of a wide range of disubstituted alkynes\nin high yields with excellent functional group tolerance. The utility\nof the developed method was further demonstrated via the late-stage\nalkynylation of pharmaceuticals and natural bioactive compounds.