Fusarolides A–C, Three Pyran-Macrolide Hybridsfrom a Marine Derived Fungal <i>Fusarium verticillioide</i> G102 as <i>Asialoglycoprotein receptor</i> 1 Inhibitorand Phytopathogenic Fungicides

Three undescribed 20-membered macrolides, fusarolides A–C (<b>1</b>–<b>3</b>), with relatively rare pyran-macrolide structures and complex chiral centers, were isolated from a marine derived fungal <i>Fusarium verticillioide</i> G102. Their chemical structures and stereoconfigurations were well elaborated. Compound <b>1</b> promoted cholesterol efflux from Huh-7 cells in a concentration-dependent manner by inhibiting <i>Asialoglycoprotein receptor</i> 1 (ASGR1), which was identified as a new therapeutic target in hypercholesterolemia in liver. Besides, compounds <b>1</b>–<b>3</b> exhibited obvious anti-phytopathogenic fungal activities.